Determination of aspirin and caffeine

Determination of aspirin and caffeine Results: Identify and mark the signals in the spectra and note the chemical shift values of the methyl resonances in aspirin and caffeine and the methylene resonance in s-trioxane. Using above expression, calculate the weight of aspirin and caffeine in one tablet, and the percentage w/w of each component in one analgesic tablet. Whole tablet weighed = 0.501 Half tablet weighed = 0.270 Mass of s-trioxane = 0.05 RMM of aspirin = 180 RMM of caffeine = 194 RMM of s-trioxane = 90 No. of moles of components = component integral/no. of protons giving signal No. of moles of standard standard integral/ no. of protons giving signal To find out the weight and percentage w/w of Aspirin and Caffience following calculations were made: Aspirin: No of moles of components (x) = ? No of moles of standard = mass of s-trioxane / RMM of s-trioxane = 0.05 / 90 = 0.000555 Component integral = 202.72 No of protons giving signal = 3 Standard integral = 200 No of protons giving signal = 6 Putting values in the above eq.1: x / 0.000555 = (202.72/3) / (200/6) x/0.000555 = 67.57 / 33.33 x = 67.57 x 0.000555 / 33.33 x = 0.00113 moles Mass of aspirin = moles x RMM = 0.00113 x 180 = 0.203g = 203mg % w/w of aspirin in the tablet = mass of aspirin / mass of the tablet x 100 = 0.203 / 0.501 x 100 = 40.5% Caffeine: No of moles of components (x) = ? No of moles of standard = mass of s-trioxane / RMM of s-trioxane = 0.05 / 90 = 0.000555 Component integral = 14.0 No of protons giving signal = 3 Standard integral = 200 No of protons giving signal = 6 Putting values in the above eq.1: x / 0.000555 = (14.0/3) / (200/6) x/0.000555 = 4.66 / 33.33 x = 4.66 x 0.000555 / 33.33 x = 0.0000775 moles Mass of caffeine = moles x RMM = 0.000075 x 194 = 0.0145g = 14.5 mg % w/w of aspirin in the tablet = mass of aspirin / mass of the tablet x 100 = 0.0145 / 0.501 x 100 = 2.89% Discussion: Comment on the chemical shift positions of the methyl groups in aspirin and caffeine. Aspirin shows about 6 singlets in the spectrum, all in different environment. It has got one methyl group which gives rise to a singlet at ? 2.3498 as there are no neighbours and the n+1 rule is followed. It has integral of 3 as three protons are giving rise to the chemical shift at ? 2.3498. The four singlets between ? 7.1292 ? 8.1123 correspond to benzene ring protons. In aspirin there is a very broad singlet at ? 11.0082 due to the carbonyl next to hydroxyl proton which shifts it towards the left hand side. Caffeine has got three methyl groups which give rise to three singlets as all the three methyl groups are in different environments to each other. All the three peaks have integral of 3 which arises due to the three protons on each methyl groups. The first singlet at ? 3.4133 is due to the protons (a) next to nitrogen with single bond. The second singlet is seen at ? 3.5910 corresponding to protons(c) next to double bonded carbon and oxygen and the last methyl singlet (b) at ? 4.004 is due to the protons next to two double bonded oxygens attached to two carbons. There is also a singlet seen at ? 7.5172 that arises due to a single proton CH between two nitrogens. Compare your results to the contents claimed by the manufacturer and discuss any differences observed. How does this method compare with determinations by UV absorbance and HPLC. What are the NMR methods limitations? UV techniques are simple and rapid. It can be used for the quantitative determination of highly conjugated compounds and metal ions. Metal ions can be coloured and determined by UV. HPLC is a separation techniques used for compounds on basis of their rate of elution and can separate complex mixtures. HPLC analysis is very quick with high resolution. The stationary column can be used repeatedly for number of times. In HPLC analysis, automated instrumentation and quantitation can be used. It also has low sensitivity and accuracy. NMR is an expensive technique. Compared to UV and HPLC the instrumentation is more costly. The sample to be analyzed has to be free of any contaminants. It takes longer time as compared to the other techniques mentioned. In NMR the chemical shift corresponds to the structure of the molecule being analysed so for compounds with similar structures it is difficult to separate the signals. Also it is an insensitive technique. References: http://www.pg.gda.pl/chem/CEEAM/Dokumenty/Warsztaty/Levsen.pdf http://wiki.answers.com/Q/Advantages_and_disadvantages_of_HPLC http://www.answers.com/topic/hplc-high-performance-liquid-chromatography http://www-unix.oit.umass.edu/~mcclemen/581Proteins.html http://wapedia.mobi/en/Ultraviolet-visible_spectroscopy http://books.google.co.uk/books?id=Dvoeg3erhRECpg=PA297lpg=PA297dq=limitations+of+nmr+spectroscopysource=blots=ea8zhh6QdCsig=v3mtaKE11Git3TMIX06mK3KD3yIhl=enei=BStBS5abEJj20wTkg6mSBQsa=Xoi=book_resultct=resultresnum=6ved=0CBoQ6AEwBTgK#v=onepageq=limitations%20of%20nmr%20spectroscopyf=false

Business Ethics Essay (grapes -- essays research papers

Business Ethics Essay   Ã‚  Ã‚  Ã‚  Ã‚  Business ethics are a moral code that people conducting any sort of business should feel honorably obligated to follow. People are definitely morally responsible to follow a code of ethics and should never cheat each other. Parts of this code of ethics should be honesty, integrity, fidelity, charity, responsibility, and self-discipline. Those ethics should apply both to a person buying something, and a person selling something. I don’t believe that a person should be forced to follow the caveat emptor policy, on the basis that it is unfair and unjust both to the buyer and seller. If you are an ethical person, you should not have to warn people to beware.   Ã‚  Ã‚  Ã‚  Ã‚  A person selling something is morally obligated t...

The Third Leg in the Strategy Tripod †Institutional Based View

THE THIRD LEG IN THE STRATEGY TRIPOD – Institutional Based View Introduction Strategy has come to play a significant role in international business (IB) in recent times. This is predicated on the fact of complexities associated with globalisation. The interplay of various factors of production in an environment could have been sufficient for MNEs in taking investment decisions. However, experience has shown otherwise. In this light, strategising in the international business arena has been dominated by industry and resource based views, somewhat ignoring the magnitude of institutional impact on investment decisions.EVALUATION OF ‘THE THIRD LEG IN THE STRATEGY â€Å"TRIPOD†Ã¢â‚¬â„¢ According to Peng et al (2008), citing Porter(1980) Barney (1991) the industry-based view is rooted in the assumption that the strategy employed by MNEs is determined by the conditions within the industry of focus. Also, the resource based view tends to narrow performance and internation al business strategy to resources in specific firms. The aggregated views are functions of research findings carried out in environments whose institutions are seemingly standardised and stable.Meanwhile these views have not been able to deal with the nagging questions posed by strategy as regards investment locations. Recent research directions have established remarkable differences in the institutional frameworks of emerging economies relative to developed economies. This is largely due to long history of cultural, legal and political platforms that organise their businesses. According to Peng et al (2008), the effect of these formal and informal institutions are quite remarkable in shaping strategies and performance even in developed economies.This may not have come to the front burner without recent research on the relationship between institutions and organisational strategies in emerging economies. Peng et al (2008) are of the view that earlier approach to international IB st rategy did not offer institutions appropriate place in the strategy discourse. In furtherance to this, Peng et al (2008) argue that the institutions should actually be recognised as the third leg in the strategy tripod. The other legs being resource based and industry based views.Let us explore the institutions and how they impact IB strategies. In understanding an institution, the renowned Economist Searle (2005 pp. 21) defines an institution as ‘any collectively accepted system of rules (procedures, practices) that enable us to create institutional facts’. It follows that the institutions set the rules for doing business in any environment. As such an MNE is only going to be successful where it understands, assimilates and applies the rules of the environment for competitive advantage.Peng et al’s (2008) argument on the institutional view of strategy focuses on legal, social and political aspects as these have been found to change quite significantly in emergin g economies upon both internal and external impacts. EFFECTIVENESS OF THE FOUR CASES OFFERED IN SUPPORTING THE CENTRAL ARGUMENT Peng et al (2008) posit that in transacting business in a developed economy, the supporting institutions operate albeit silently at the background. This is in contrast to the situation in emerging economies where the weight of institutions plays visible roles in consummating transactions.These visible roles have tendencies to alter the business equation in favour of MNEs who have taken proactive steps in influencing the institutional outcomes. Place this fact side by side the growing importance of emerging economies, it becomes imperative that institutional view of strategy becomes as important as the traditional views. Emerging economies like China and India are great examples where institutions’ actions and inactions play great roles in balancing the IB strategy tripod. Growing The Firm In ChinaPeng et al (2008) note that it is puzzling to see Chin a growing economically in the midst of underdeveloped institutional framework. This growth could not have taken place on the strength of the industry and resource based views alone. Peering deeply, Peng et al (2008) Wong (2012) recognise the cultural influences that abound in Chinese business climate which border on social and family networks otherwise referred to as guanxi. This may have phenomenally replaced the formal institution, as such affects the success of businesses within the environment.Peng et al (2008) suggest that in economic environments where institutions are week, norms and cognition take over as game changers. This highlights the import of institution based view in IB strategies. Competing In And Out Of India The meteoric rise of India in the area of IT and Business Process Outsourcing (BPO) was attributed to resource and industry based view of IB strategy (Peng et al 2008). These views are based on the opinion that cheap labour, excellent skills and virtuality are major factors responsible for their growth.Nonetheless, institutional considerations are found to be quite relevant in India’s context. Considerations in the areas of education subsidy to top Universities and various economic reforms including liberalisation by government institutions played crucial roles in making India a competitive environment for investments (Peng et al 2008). These institutional references can conveniently stand as the third tripod of the IB strategy. Antidumping As Entry Barriers Market-based variables as noted by Peng et al (2008) have been alleged as the basic entry barriers in IB.Meanwhile non market based institutional variables have been largely ignored in IB startegies.. Trade barriers have come to play important roles in IB strategies. Countries in protecting their local business players against foreign competition usually set up institutional policies aimed at stemming imports by foreign MNEs. These MNEs are alleged to compete unfavourably thro ugh the process of dumping. Davis (2009) citing the 1947 GATT agreement defines dumping as a situation where goods originating from a country are imported into another country at less than normal values.The use of anti-dumping laws by developed countries against MNEs from developing countries is a good example of how an institutional policy could be a tool of trade barrier in IB. Western countries have used this tool of protectionism against competition from Asia quite effectively. The issue here is that when market-based forces fail, antidumping laws could be deployed by local firms to ward off MNEs, thus firming the position of institutional based view as the third leg in the IB strategy tripod. Governing The Corporation In Emerging Economies Corporate governance is highly a determinant in firm performance in developed countries.This is due to the fact that the agency theory focuses on separation of ownership and control. These are exemplified by principal-manager conflicts (Peng et al 2008) quite unlike a lot of emerging economies where principal-principal conflict is the norm. The ability of an MNE to invest in such an environment would mean understanding the value and complexities of concentrated ownership and strategising accordingly. CONCLUSION It is evident from the work of Peng et al (2008) and other researchers that institution-based view has come to occupy the third leg of the IB strategy discourse.It is pertinent to note that the emergence of the institution based view does not in any way diminish the importance of the traditional based views in IB strategy. Instead it complements the traditional views, thus balancing the IB strategy in form of a tripod. It is my opinion that this tripod leverages on industry-based view, resource-based view and institutional-based view for balance. While Peng et al (2008) referenced most of their arguments on developing economies, the institutional effects are found to be applicable in developed countries as well. References Davis L. 2009) ‘Ten years of anti-dumping in the EU: economic and political targeting’. ECIPE Working Paper †¢ No. 02/2009 (Online) Available from: http://www. ecipe. org/media/publication_pdfs/ten-years-of-anti-dumping-in-the-eu-economic-and-political-targeting. pdf (Accessed September 26, 2012) Peng, M. W. , Wang, D. Y. L. & Jiang, Y. (2008) ‘An institution-based view of international business strategy: A focus on emerging economies’,Journal of International Business Studies,  39 (5), July/August, pp. 920–936. (Online) Available at: http://dx. doi. org. ezproxy. liv. ac. k/doi:10. 1057/palgrave. jibs. 8400377 (Accessed September 23) Searle J. (2005) ‘What is an institution? ’ Journal of Institutional Economics (2005), 1: 1, 1–22 (Online) Available from: http://www. laisumedu. org/DESIN_Ibarra/desin/pdf-seminario2006/seminario-2006-04d. pdf (Accessed September 24, 2012) Wong J. (2012) ‘The Guanxi Strategie s of Taiwanese Firms in China’s Economic Reforms’ The Journal of Global Business Management Volume 8 * Number 1 * February 2012. (Online) Available at: http://www. jgbm. org/page/15%20Jeng-Min%20Wong. pdf (Accessed September 24, 2012)

Self-recommendation Essay

I am convinced to say that my secondary school life is not in vain because I have acquired both academic knowledge from lessons and practical experience from various extracurricular activities. Being a leader in the Scout, I realized that organization, time management and communication are of paramount importance in leadership. Being a senior patrol leader, I engaged in planning meetings for the scout members. In addition to briefing and communicating with the whole troop of scouts, I had to cooperate well with teachers in order to convey the messages clearly from teachers to all the scout members as well as consolidating the spirit of scouts. To become a more capable leader in a team, I would like to make progress in my leadership skill, especially the organization and management skills, and to capitalize on different aspects. Therefore, I determine to have further study on management, contributing myself to help people to organize and manage their business. Apart from leadership, I feel satisfied as long as helping someone who is in need. Through studying in science subjects, I found that nowadays advanced technology is established by the forerunners who devoted themselves to this industry, such as Steve Jobs. Definitely, the development in science and technology has brought convenience to our life. Although I am not going to become an inventor, I am willing to have further study on science technology in order to light up people’s life. Thus, I am enthusiastic in studying subject related to science and technology to equip myself to help people. All in all, I have recognized myself in the past few years. To show the gratitude to my teachers and friends, I would endeavor to show my best positive light on different fields. I look forward to my new journey in the future.

The Affect or Effect Conundrum and How to Solve It

The Affect or Effect Conundrum and How to Solve It Lets face it- the English language has some confusing grammar rules. In fact, some words in the English language are so confusing that incorrect usage is more common than correct usage- and affect vs. effect are two such words!A problem many people have with understanding the difference between affect and effect is that there is only one letter that distinguishes the two from each other. Beyond that, affect is defined as to have an effect on so their definitions are similar. Then, both words sound almost the same when spoken quickly, creating further confusion. So, lets take a look at these two words and discuss a failproof way to remember the difference between them.AffectAffect is a verb that means to have an effect on; make a difference to; touch the feelings of (someone); move emotionally. However, there is one instance in which affect is a noun- when it refers to the way someone carries themselves or their outward demeanor. This usage of affect is uncommon, so it isnt a context youll encounter often unless youre in certain fields, where someone might refer to the patients affect (in psychology), meaning their disposition and how they outwardly present themselves.Examples:The extra side dish doesnt affect the cost of the mealIt doesnt affect me to watch sad movies, so I usually only laugh at them.EffectEffect is almost always a noun and can mean: a change that is a result or consequence of an action or other cause; an impression produced in the mind of a person. Effect can also mean: the lighting, sound, or scenery used in a play, movie, or broadcast, as in movie special effects.Examples:The effect of that movie on the audience is undeniable.Those lights have a nice effect on the look of the painting.And since it seems to be impossible to have an easy time with these two words, there is also one instance in which effect is used as a verb. When you effect change, you bring about change, and youll see it almost always combined with change in this context.The Raven EffectIf you want an easy mnemonic device to help with the affect vs. effect conundrum, you can think of the word RAVEN to Remember Affect is a Verb and Effect is a Noun. Just keep in mind that there are a few instances where this isnt always the case, but for most contexts and of the words, it is.Affect vs. Effect in a nutshell

Social Economics Within the Great Gatsby Essays

Social Economics Within the Great Gatsby Essays Social Economics Within the Great Gatsby Paper Social Economics Within the Great Gatsby Paper Essay Topic: Economics Instead, Fitzgerald explores two efferent classes of the wealthy. There are individuals, like Jordan Baker, who were born into their wealth. Her family has most likely had money for generations on end. Because of this they are called old money. In The Great Gatsby, the people who are born into old money do not have to work, do not talk about their wealth, and are able to go through their days entertaining themselves with whatever makes them happy. The characters who represent this group, Tom, Daisy, and Jordan, are most likely the most selective group, making distinctions of a persons kind of wealth. They base heir decisions not on how much wealth a person has, but on how long that person has had their wealth and how they made It. In the asses Gatsby and many others acquired their wealth. People like this were considered new money. The fact that these people are new money is enough reason for old money people, like Tom and Daisy, to not include them in their circle. According to the old money way of thinking, new money people could never have their kind of taste and sophistication. Not only does Gatsby work, but his origins are from a poor class, which means that he could not be good enough for Daisy. Daisy, coming from old money, is Judgmental and shallow. When she first met Gatsby, she decided she could not possibly be with him because of his lack of money. She failed to look at the essence of Gatsby and realize that this man was hard working and willing to make more money. Instead, she believed that she was superior and could not stoop to love a man without as much money as she. But are people from new money any different? If we look at Gatsby new money party-goers, we see that they attend his parties uninvited, they eat and drink his food, yet they dont show the courtesy to meet Gatsby. After Gatsby death, hey do not even show up to his funeral. Obviously, Fitzgerald does not show either the new or old money characters in a complimentary light. Their highest priority is living for today, the next party, and on what they can spend their money. Fitzgerald did a Just as explicit a job when portraying the middle class. Nick, even though he is from a family with some wealth, does not have by any means as much money as Tom or Daisy. In the end, he is revealed as a man with principles and integrity. He is confident In himself and his accomplishments and Is, therefore, able to mingle among the classes. In a word, Nick Is content. Myrtle, though, Is on the other side of the middle class spectrum. She Is currently married too middle class man, but Is a leads her into having an affair with Tom. Because of this need, Myrtle has distanced nearest Trot morals, Ana NAS no problem accenting on nerd NASDAQ IT It means Tanat for a short while she can live the lifestyle she desires. The Great Gatsby is often viewed as Fitzgerald masterpiece. It portrays an accurate picture of American society in the asses. The asses were filled with post-war economic growth, and Fitzgerald presents the frenzy of society to take part in that growth. The characters in the novel exemplify the ease with which new and greed can derail ones moral code. Other characters, especially those in the old money class, are only minimally aware that a moral code even matters. At the same time, Fitzgerald portrays a third group represented by Nick. These people stand apart from the social frenzy. They hold their moral code above the quest for wealth. They live apart from the lure of social class. Despite the wish of many to view America as a classless society, The Great Gatsby reveals that class distinctions not only exist but also define acceptable behavior.

A Drug Induced Psychosis Health And Social Care Essay

A Drug Induced Psychosis Health And Social Care Essay Within this Independent study drug induced psychosis will be looked at. Within the first two pages a definition will be given as well as a brief history. This will be followed by a discussion on drug induced psychosis how individual is a affected and what is the cause. The author will then look at the drugs and how they affect people mentally and physically as well as how they affect the brain. When the final few pages it the author will look at the evidence and literature available for drug induced psychosis before then commenting on personal recommendations and the conclusion of all findings. The rationale behind choosing this topic was simply that more and more people through subculture and their own vulnerabilities are accepting of drug however through their own naivetà © and lack of understanding are consequences he consequences and consequences Definition According to Mosby (2009), drug induced psychosis is a psychotic state caused by an excessive dose of both illegal and the rapeutic drugs. This is supported by the West Australian Department of Health [WADOH](2009) who defines stimulant-induced psychosis, as an episode where the use of a legal or illicit drug has caused a psychiatric illness where the reality of the patient is impaired. The impairment of the patient can also include hallucinations or delusions, which can cause additional communication problems or social interaction difficulties. The drug induced psychosis according to WADOH (2009) may also be as a result of the overuse or abuse of prescription medication, or the outcome of a history of illicit drug abuse. Brief history Razool (1998) describes the historical evidence for substance abuse dating back thousands of years. Tobacco, alcohol and other psychoactive drugs have bee used by different societies for medical, religious, cultural and religious purposes and acts as a social lubricant. Today there is no lack of interest in the use of psychoactive substances and plants. Alcohol and drug u se remain part of the social and psychological fabrics of our society and are now regarded as a public health problem. Attitudes towards drug use have changed during various stages historically and even with harsh laws, there still remains problems in society where drug education and drug treatment is required by society (Razool, 2008). Tea, coffee and tobacco have all been illegal in Britain at some stage (Whitaker, 1987 cited by Razzol, 2008). Alcohol and drug use can cause a host of physical, social, psychological and economic harm, not only to the individual, but also to the family and the wider community. If the individual has previously had psychosis the use of drugs or alcohol can increase the likelihood of another psychotic event. This is due to the fact that the individual can become emotionally unstable, due to their drug use along with their loss of cognitive processing and therefore, inhibits the chemical balance of the brain (Royal Brisbane and Women’s Hospital, 2009). Within this section use critical analysis and relevant referencing to show a lack of information provided and the difficulty clinical nurses face while battling this. Drug induced psychosis